Vitamin D and MS

SHOULD WE KEEP WAITING FOR MORE RESEARCH OR SHOULD WE SIMPLY INCREASE OUR VITAMIN D INTAKE TO OPTIMIZE RECOMMENDED BLOOD LEVELS?

Research reported in the December (2011) edition of The Annals of Neurology points again to the link between vitamin D deficiency and multiple sclerosis.

Oxford University researchers, along with Canadian colleagues at the University of Ottawa, University of British Columbia and McGill University, set out to look for rare genetic changes that could explain strong clustering of MS cases in some families in an existing Canadian study.

Prof George Ebers, lead study author at Oxford University, says the odds are overwhelming. "All 35 children inheriting the variant is like flipping a coin 35 times and getting 35 heads, entailing odds of 32 billion to one against." He added: "This type of finding has not been seen in any complex disease. The uniform transmission of a variant to offspring with MS is without precedent but there will have been interaction with other factors."

Prof Ebers believes that this new evidence adds to previous observational studies which have suggested that sunshine levels around the globe - the body needs sunshine to generate vitamin D - are linked to MS. He maintained that there was now enough evidence to carry out large-scale studies of vitamin D supplements for preventing multiple sclerosis.

"It would be important particularly in countries like Scotland and the rest of the UK where sunshine levels are low for large parts of the year. Scotland has the greatest incidence of multiple sclerosis of any country in the world."

Dr Doug Brown, head of biomedical research at the MS Society, called it an important development.

"This shines more light on the potential role of vitamin D deficiency on increasing the risk of developing MS."